Medications that dialyze easily are all EXCEPT:

The reason digoxin is considered a medication that does not dialyze easily is primarily due to its large volume of distribution and high protein binding. These characteristics mean that digoxin remains largely in the tissues and only a small percentage of the drug is present in the bloodstream during dialysis. Additionally, digoxin's pharmacokinetics show that it equilibrates quickly in tissues, making it difficult for dialysis to efficiently remove it from the system compared to other substances that are more readily cleared by the dialysis process.

In contrast, medications such as gentamicin, tobramycin, and vitamin C have pharmacokinetic profiles that allow them to be more easily dialyzed. Gentamicin and tobramycin, both being aminoglycoside antibiotics, are primarily eliminated by the kidneys and have lower protein binding, allowing for effective removal during dialysis sessions. Vitamin C, being a small and water-soluble molecule, also has a high clearance rate during dialysis.

Understanding the nuances of how different medications interact with the dialysis process is vital for managing patient care effectively, particularly concerning the removal of drugs that may have toxic effects if they accumulate in the body during treatment.